A Better Way to Diagnose Exercise-Induced Bronchoconstriction (EIB) and Asthma in Children

Aridol logo

Recommended in major guidelines to identify EIB

ARIDOL® (mannitol challenge test) is indicated for the assessment of bronchial hyperresponsiveness (BHR) in adult and pediatric patients 6 years of age or older who do not have clinically apparent asthma. BHR is a key clinical feature of respiratory conditions such as exercise-induced bronchoconstriction and asthma.1

A young boy on a running track having asthma symptoms

Easier on Children

Does not require physical exercise

Does not require motor skills2

Shorter test time than exercise test3
Progressive dose-response avoids large falls in lung function3
A nurse with a child in a hosptial hallway

Better for Providers


Simple to administer

No exercise equipment needed

Can be used in a variety of clinical settings

“Exercise challenge testing in the Pediatric population is often inconclusive due to deconditioning, difficulty achieving target HR and oximetry artifact. Aridol testing has none of the above challenges and it can also provide the Physician with an indication of airway reactivity severity.”

Bruce Brown, MS, RRT, AE-C

Nemours Children's Health

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Methapharm Respiratory Logo

Focused on every breath

At Methapharm Respiratory we take pride in working with healthcare practitioners to support the right diagnosis for patients exhibiting common respiratory symptoms such as cough, wheeze and shortness of breath. Asthma symptoms are shared across many respiratory conditions and misdiagnosis can easily occur, resulting in patients being placed on ineffective treatments.

Methapharm Respiratory supports clinicians in the diagnostic process with methacholine and mannitol challenge tests as objective measures of airway hyperresponsiveness.

We also offer training and education (CRCE) at no cost.

For more information, please contact Methapharm at
1-833-887-7686, send an email or visit www.aridolchallenge.com

A graphic of lungs

Aridol® (mannitol inhalation powder)
INDICATION: ARIDOL is a sugar alcohol indicated for the assessment of bronchial hyperresponsiveness in adult and pediatric patients 6 years of age or older who do not have clinically apparent asthma.


Mannitol, the active ingredient in ARIDOL, acts as a bronchoconstrictor and may cause severe bronchospasm. Bronchial challenge testing with ARIDOL is for diagnostic purposes only. Bronchial challenge testing with ARIDOL should only be conducted by trained professionals under the supervision of a physician familiar with all aspects of the bronchial challenge test and the management of acute bronchospasm. Medications (such as short-acting inhaled beta-agonist) and equipment to treat severe bronchospasm must be present in the testing area. If severe bronchospasm occurs it should be treated immediately by administration of a shortacting inhaled beta-agonist. Because of the potential for severe bronchoconstriction, the bronchial challenge testing with ARIDOL should not be performed in any patient with clinically apparent asthma or very low baseline pulmonary function tests (e.g., FEV1<1-1.5 liters or <70% of the predicted values) [see Warnings and Precautions (5.1) of the Prescribing Information].


  1. Aridol package insert, revised 08/2021.
  2. E. Kersten, J. Dressen, J. Berg, et al. Mannitol and Exercise Challenge Tests in Asthmatic Children. Pediatr Pulmonol. 2009;44:655–661
  3. J. Brannan, H. Koskela, S. Anderson, et al. Responsiveness to Mannitol in Asthmatic Subjects with Exercise- and Hyperventilation-Induced Asthma. Am J Respir Crit Care Med. 1998;158:1120–1126

Aridol® is a registered trademark of Pharmaxis Ltd. 20 Rodborough Rd, Frenchs Forest NSW 2086, Australia. Aridol is distributed by Methapharm, Inc. in the United States.

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