Guidelines / Publications

Provocholine®

Aridol®

Partnerships

Training

Clinical Research Consultation

CRCE Courses

Blogs / Podcast

Guidelines / Publications

Speaking Engagements

Guidelines

Guidelines

Asthma: diagnosis, monitoring and chronic asthma management, NICE 2021

An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FeNO) for clinical applications, Dweik, 2011

British guideline on the management of asthma, BTS 2019

Effectiveness of FeNO-guided treatment in adult asthma patients: A systematic review and meta-analysis, Korevaar 2023

ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests, Coates 2017

ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing, Hallstrand 2018

European Respiratory Society Guidelines for the Diagnosis of Asthma in Adults, Louis 2022

European Respiratory Society clinical practice guidelines for the diagnosis of asthma in children aged 5–16 years, Gaillard 2021

A European Respiratory Society technical standard: exhaled biomarkers in lung disease, Horvath, 2017

Exercise-induced bronchoconstriction update, Weiler 2016

Global Strategy for Asthma Management and Prevention, GINA 2022

Management of severe asthma: a European Respiratory Society/American Thoracic Society guideline, Holguin 2020

Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement, Graham 2019

Use of Fractional Exhaled Nitric Oxide to Guide the Treatment of Asthma: An Official American Thoracic Society Clinical Practice Guideline, Khatri 2021

 

 

Publications

Diagnosing Asthma

Reevaluation of diagnosis in adults with physician-diagnosed asthma, Aaron 2017

Underdiagnosis and Overdiagnosis of Asthma, Aaron 2018

Misdiagnosis of Asthma in Schoolchildren, Yang 2017

(Correcting) misdiagnoses of asthma: a cost effectiveness analysis, Pakhale 2011

Bronchodilation Test with Inhaled Salbutamol Versus Bronchial Methacholine Challenge to Make an Asthma Diagnosis: Do They Provide the Same Information? Louis 2020

Usefulness of mannitol challenge testing for diagnosing asthma in everyday clinical practice, Pedersen 2020

Inhaled Mannitol in the Diagnosis and the Management of Asthma, Anderson 2016

Diagnostic properties of inhaled mannitol in the diagnosis of asthma: A population study, Sverrild 2009

IOC Consensus Statement on Asthma in Elite Athletes, Ljungqvist 2008

Diagnosing EIB

Bronchial Provocation testing for the Identification of Exercise-Induced Bronchoconstriction, Brannan 2020

Mannitol dry powder challenge in comparison with exercise testing in children, Barben 2011

Mannitol and Exercise Challenge Tests in Asthmatic Children, Kersten 2009

 

Bronchial Challenge Testing in Children

Inhaled Mannitol Identifies Methacholine-Responsive Children with Active Asthma, Subbarao 2000

Mannitol and Exercise Challenge Tests in Asthmatic Children, Kersten 2009

Mannitol dry powder challenge in comparison with exercise testing in children, Barben 2011

The Safety and feasibility of the inhaled mannitol challenge test in young children, Alblooshi 2013

Methacholine challenge testing is superior to the exercise challenge for detecting asthma in children, Zaczeniuk 2015

Predictive Factors for a Shortened Methacholine Challenge Protocol in Children, Proulx 2020

 

Sensitivity and Specificity

Usefulness of mannitol challenge testing for diagnosing asthma in everyday clinical practice, Pedersen 2020

Inhaled mannitol in the Diagnosis and the Management of Asthma, Anderson 2016

Diagnostic properties of inhaled mannitol in the diagnosis of asthma: A population study, Sverrild 2009

The Assessment of Validity of Different Asthma Diagnostic Tools in Adults, Yurkadul 2005

A Comparison of the Validity of Different Diagnostic Tests in Adults with Asthma, Hunter 2002

Safety and Efficacy

Methacholine bronchial provocation test for assessment of bronchial hyperresponsiveness in preschool children, Li 2019

Bronchial Provocation with Methacholine: Literature Review on Safety, TechEd 2010

The Safety and feasibility of the inhaled mannitol challenge test in young children, Alblooshi 2013

The Safety and efficacy of inhaled dry powder mannitol as a bronchial provocation test for airway hyperresponsiveness: a phase 3 comparison study with hypertonic (4.5%) saline, Brannan 2005

Methacholine challenge testing: Safety of low starting FEV1, Martin 1997

Usefulness and safety of pharmacologic Bronchoprovocation challenge in evaluating patients with normal spirometric tests who are suspected of having asthma. Pratter 1988

The Clinical value of pharmacologic bronchoprovocation challenge, Pratter 1984

Methacholine inhalation challenge studies, Townley 1979

Screening in Military, Police Forces and Fire Fighters

Baseline Spirometry as a Predictor of Positive Methacholine Challenge Testing for Exertional Dyspnea, Hunninghake 2022

Asthma tests in the assessment of military conscripts, Miedinger 2010

Diagnostic Tests for Asthma in Firefighters, Miedinger 2007

Use of Mannitol (Aridol) Bronchial Provocation Testing (testing for Australian Defence Force Personnel), Australian Government (Department of Defense) Health Bulletin No 8/2006

Assessing Occupational Asthma

The efficacy and safety of mannitol challenge in a workplace setting for assessing asthma prevalence, Menezes 2018

Use in Clinical Trials and Drug Development

The use of the mannitol test as an outcome measure in asthma intervention studies: a review and practical recommendations, Sverrild 2021

FDA Draft Guidance on Albuterol Sulfate, Mar 2020

Cost-Effectiveness of Objective Testing

Cost-effectiveness of implementing objective diagnostic verification of asthma in the United States, Yaghoubi 2020

(Correcting) misdiagnoses of asthma: a cost effectiveness analysis, Pakhale 2011

Beta Blockers and Response to Salbutamol

The impact of regular bisoprolol on response to salbutamol in asthma: A double-blind randomized placebo-controlled crossover trial, Bennett 2020

FeNO Guided Management of Asthma

Exhaled nitric oxide levels to guide treatment for adults with asthma, Petsky, 2016

Exhaled nitric oxide levels to guide treatment for children with asthma, Petsky, 2016

The Clinical Utility of Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management, Wang 2017

FeNO for Management of Inhaled Corricosteroids

Use of exhaled nitric oxide measurements to guide treatment in chronic asthma, Smith 2005

Anti-inflammatory treatment of atopic asthma guided by exhaled nitric oxide: a randomized, controlled tria, Sky 2011